1.
Experimental & Molecular Medicine
;
: 52-58, 2008.
Article
in English
| WPRIM
| ID: wpr-219393
ABSTRACT
Rutin, a glycoside of flavonol, inhibits osteoclast formation induced by receptor activator of NF-kappaB ligand (RANKL) in bone marrow-derived macrophages. It reduces reactive oxygen species produced by RANKL and its inhibitory effect results from reduced levels of TNF-alpha Rutin also lowers NF-kappaB activation in response to RANKL.